Researchers are increasingly using circular single-stranded DNA (CssDNA) for applications including gene editing, cell therapy, DNA vaccines, and gene regulation because of its improved stability and performance.
We're excited to introduce our Custom CssDNA Synthesis Service, offering flexible sequence design, reliable synthesis, and comprehensive quality control.
 
Case Study
We successfully converted a 50 nt 5'-phosphorylated linear ssDNA into its circular form. Mass spectrometry confirmed the expected 18 Da molecular weight reduction after cyclization with minimal byproducts, demonstrating efficient circularization and high product purity.
Uncyclized linear lead material spectrum Cyclized cyclic lead material spectrum


Why Choose Our CssDNA Synthesis?
 • Enhanced Stability – Resistant to exonuclease degradation for improved intracellular persistence.
 • Superior Transfection Efficiency – Outperforms linear DNA in hard-to-transfect cells, ideal for gene therapy and DNA vaccines.
 • Broad Applications – Suitable for gene editing, cell therapy, DNA vaccines, viral vectors, and nanomedicine.
 • Fully Customizable – End-to-end support from sequence design to synthesis and QC.  
If you're exploring Circular ssDNA for your next project, we'd be happy to discuss your design requirements and help determine the best solution for your application.
 
Discover how our Custom CssDNA Synthesis Service can support your next project.

 
 
 
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Synbio Technologies LLC
9 Deer Prk Dr., Suite J-25, Monmouth Junction, NJ 08852, USA